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KMID : 0358320060470050536
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Korean Journal of Urology
2006 Volume.47 No. 5 p.536 ~ p.540
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Efficacy of Combination Therapy for Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome: A Prospective Study
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Mo Kyo-Ik
Lee Kyung-Seop
Kim Dae-Gon
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Abstract
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Purpose: The National Institute of Health(NIH) category III chronic nonbacterial prostatitis/chronic pelvic pain syndromes(CPPS) are commonly seen disorders; however, there has been no consensus on how to manage these patients. The purpose of this trial was to compare the efficacy of antibiotic monotherapy and antibiotic plus alpha-blocker combination therapy for the treatment of CPPS patients.
Materials and Methods: The study was comprised of 54 patients who were randomly placed into two groups: group I was treated with levofloxacin alone(28 patients), and group II was treated with levofloxacin and alfuzosin(26 patients). The levofloxacin, or the levofloxacin and alfuzosin were given to the respective groups for 8 weeks. The NIH Chronic Prostatitis Symptom Index(NIH-CPSI) was evaluated both before and after the treatment.
Results: Before the treatment, the mean CPSI of the group I patients was 23.1±8.1, and after the treatment, it was 15.6±5.6. For the group II, the mean CPSI before the treatment was 23.9±8.3, and after the treatment, it was 11.0±4.5. The difference between the pre- and post-treatment CPSI scores of group II was significantly larger than that of group I(p=0.001). The mean differences of the CPSI from the initial scores to the final scores in both groups were followed: ±2.2 in group I and ±4.3 in group II for the pain domain, ±1.5 in group I and ±2.8 in group II for the urinary domain, and ±3.8 in group I and ±5.7 in group II for the quality of life domain.
Conclusions: Combination therapy of levofloxacin with alfuzosin appeared more effective for treating patients with chronic prostatitis/chronic pelvic pain syndrome than just administering antibiotic alone. (Korean J Urol 2006;47:536-540)
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KEYWORD
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Pelvic pain, Chronic disease, Antibiotics, Adrenergic alpha blockers
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